The FDA expands the availability of generic Doxycycline

September 20th, 2008

No matter what the status of a drug as patented or not, it’s for the FDA to regulate all manufacturing for distribution within the Europe. The good news for consumers is that this August has seen the FDA license the Lannett Company Inc. to produce the whole range of Doxycycline tablets from 50mg through 150mg. This newly licensed company is a specialist generic manufacturer and its appointment really improves the supply of this important antibiotic across all U.S. states. If you can’t find it in your local pharmacy, you guarantee to buy Doxycycline online.

Doxy is one of the tetracycline antibiotics that was developed during the 1960s by Pfizer Inc. Tetracycline is well-known and is used for treatment even in evolving countries. Being a little long in the tooth, it has passed out of patent protection so there are now generic versions on the market. That means if you are unlucky and contract one of the infections caused by a susceptible bacterium, you have a cheap cure available. So if you’re down with pneumonia, a respiratory or urinary tract infection, one of the sexually transmitted diseases or something less common, reach for Doxycycline.

Buying drugs online is better say researchers

September 16th, 2008

Shopping online can improve your mood because of its incredible convenience. Whether people should be allowed to buy drugs over the internet is more controversial. So the Mayo Clinic Proceedings has just published some research from Utah. One thousand men with ED were splitted into two groups. One bought Cialis online, the other went to see their local health providers.

The headline is that buying Levitra online was “safer”. Obviously, both groups got the drug in its full strength version. There were no problems in delivery. The key advantage to buying online lay in “patient education”. People buying online received targeted email messages about the product and how to use it safely. It’s alarming that physicians should prove so bad at communicating with their patients. Some allowances can be made because those in general practice are under great pressure to see patients quickly. Combined with the more general introductory material available online, patients were better informed than those who went to see a physician. Amazingly less than half the patients who had a face-to-face discussion with their physician were given any instructions on how to use the medication safely. But, not to give proper directions on safety. . .

Well, everyone should make the change. It’s official. Buying Cialis (or any other drug for that matter) online is better. This will reduce the number of patients asking for prescriptions and give doctors more time to do a better job.

McCain ducks Viagra question

September 8th, 2008

Swings and roundabouts. Anyway, let’s not get into that. When asked the question, McCain gave one of those straight answers he is so famous for, “I don’t know enough about it to give you an informed answer because I don’t recall the vote.” Did you see that one of the side effects of Viagra is amnesia? The FDA is going to require a warning on labels. Looks like McCain has been using Viagra just a little too long if he can’t remember how he votes on important political issues. And just so you don’t get confused, I’m against gender discrimination in any and every form.Back in July, Maraev was asked about his voting record on medical insurance. With abortion such a hot button issue in the Presidential Election campaign, someone asked him a direct question - makes a refreshing change to find someone who have enough bravery to ask a politician for a straight answer on ED pills. It went along the lines, “Did you vote in the Senate against a proposal to require insurance companies to cover contraceptive products?” To give you a little background, most private medical insurance companies will not cover the cost of any contraceptive product but will pay for their male policy holders to get their Viagra. Now far be it for me to suggest this is a tad sexist - men set the terms of every policy and they favor the men who pay the premiums.

What’s with the spam filter these days?

September 5th, 2008

Every few minutes my inbox gets another of those annoying spam messages telling me how wonderful Viagra is or how fucking good the big penis is. Gone are the days when I could just tweak the filter to include the latest permutation on Viagra. Now these clever spammers are into jpgs and all kinds of other tricks to get through the mail servers. Images are hard to filter out. It’s not that I mind being reminded every now and then what the wonderful little blue pill can do. Well, I’ve just had a déjà vu moment all over again. When I was just starting out in IT back in the 70s, one of the standard tools was ASCII, what means American Standard Code for Information Interchange - a code for characters, numbers, symbols, etc. And what did we clever people do when we got bored? We made pictures out of all those characters. And guess what’s just popped into my inbox. You got it. It’s a headline with the message built out of ASCII. So it made me sit up and take notice - just like taking Viagra really. Spammers have found a new way to beat the filters and firewalls.

Pesky ticks on the march

September 2nd, 2008

So, the summer has finished. What will come next? The answer is: bad news. The number of cases has been increasing dramatically and the infections are getting more virulent. Why is this happening? Because more people are building their houses out in the countryside where there are deer and other animals that carry the ticks. Now add in climate change, e.g. global warming. It’s influencing tick feeding behavior. The result is a surge in the number of serious cases of infection.
But still we’ve got some good news to tell. The good news is that Doxycycline continues to be a steady performer. You pop the pills for two to four weeks, and the infection clears up. So this year, more people are getting the chance to see this antibiotic at work. But over the next two years, there likely to be a change. The Center for Disease Control has begun development of a slow release version of cheap Doxycycline. This may be by injection or by patch for those who are needle-shy. The goal will be achieved, if you can get maximum effect from the tablets in not more than two weeks. Until this comes out of the lab, you’ll just have to pop the tablets, but life may soon improve.

Xanax is the most popular benzodiazepine in the US

September 1st, 2008

Pfizer, Xanax provider, wins market grand-prix every year. They help customers believe this drug is so popular because it really works. Well, that’s true to some extent. If you take xanax for the right reasons and under proper medical supervision, it does reduce levels of panic and anxiety. But still it’s one of the benzodiazepines. That means it’s habit-forming. Take it for too long or at too high a dose and you’re likely to get hooked. So before you go down this path, think carefully.

Government position

The US Government now accepts that prescription medications are routinely abused. You only have to go into the emergency departments of hospitals to see the truth of this. This drug gives you a breathing space. Use that opportunity to get counseling and therapy. In the medium to long term, psychological support is the way to learn how to control your fear and worry. Live life the natural way, don’t pay endlessly for “help” through a bottle of tablets. In 2005, there were more than 2 million admissions caused by the non-medical use of drugs. Add in the continuous barrage of advertisements for drugs, and people are persuaded to take FDA-approved medications without worrying about the consequences. The way the world works today, people do need help. Drugs like xanax really do help them to cope with the stress. But it’s not helpful to see drugs as the only solution. Yes, xanax relieves depression, but you don’t want to become an addict. You need to change yourself.

What is he thinking?

August 26th, 2008

For once, I’m going to put on my robe and give you the view from the other side.

So my patient has walked through the door and, in the same breath as blurting out that he’s suffering ED. I know Pfizer Inc. did a wonderful thing when they invented Viagra, cialis and other, but that medication so dominates the public consciousness that many men seem have never even heard about Cialis or Levitra, let alone all the other treatments that are available and may be necessary. Still even though my patients are predictable, they are at least coming through the door to get treatment. Ten years ago that did not happen. The world is a better place thanks to Pfizer Inc.

It is common tendence that patient doesn’t notice any improvement that take place in his disease history. his weight looks much as it was the last time we met. During the physical, I’ll look for acanthosis nigricans which are darker patches of skin in the arm pit or round the neck. I may also do a blood sugar test just to be thorough. Blood pressure tests out in the normal range, so that’s another good sign.

My first motion was to review the medical records to see if there were any immediate clues. If there are diseases or one of the medications currently on prescription has an ED side effect, we have solved the case before we start. I should let you in on a small medical secret. About a quarter of all the cases that we see are drug-related. Usually, we simply change the medication and the ED goes away. Alternatively, we have to counsel lifestyle changes because the excessive alcohol consumption or recreational drug of choice is not doing the patient any favors.

The questions are designed to establish whether we’re dealing with problems of desire (which could be psychological or physical), whether it’s purely ED or there are also problems with ejaculation and orgasm, and to check up on those lifestyle choices which could be the real problem.

The physical examination tries to cover as many possibilities as possible in as short a time as possible. Most men find an examination deeply embarrassing so keeping it short is a “good thing”. I’m looking for anything that might suggest a systemic problem. So, I’m obviously going to start with the penis. Some of my questions have probed whether the penis has changed shape in any way or perhaps the erection is painful. A physical examination could find evidence of lumps or the answers to the questions may reveal that the penis now bends or curves when erect, all of which could suggest Peyronie’s disease. Similarly, if the penis is not sensitive when I touch it, this may indicate possible problems in the peripheral nervous system.

If the testicles feel slightly smaller than I would expect, this can suggest a low testosterone level. Following the same idea and taking a quick overview of the body also allows me to look for any changes to the usual distribution of body hair or any enlargement to the pectorals (a polite way of suggesting that my patient may be developing small breasts). Any such abnormality can indicate problems with the hormone balance or the endocrine system. I’m also testing the pulses in both the wrists and ankles. If there are any circulatory problems, I’m likely to find a decrease pulse at the extremities.

So these are all the quick and easy explanations. In most cases, there is little to suggest the need to go on to further tests and I can then get into a discussion of the medication options. This is when the patient finally begins to look more comfortable again. We have finally come back to his original questions, except that I’m also telling him about Cialis and Levitra. Viagra may have the name, but Cialis in particular does have some interesting characteristics.

Insomnia in our life

August 22nd, 2008

Appropriately enough for a site devoted to Ambien, it is Insomniac by Gayle Greene. So here is an autobiographical take on what it is like to live with insomnia by a woman who ought to know. Gayle Greene has the distinction of being a non-professional member of the American Academy of Sleep Medicine (AASM). She wins this prize even though not a medical researcher because she is the “patient representative” on the board of the American Insomnia Association, which operates within the AASM’s umbrella. This latest tome (quite heavy at 520 pages) adds to her impressive resume of academic publications. The only man who can really tell you what it is like in a foreign country is one who has been there. For those of us who have always been able to sleep without difficulty, insomnia is like a foreign country, and the idea of having to use a medication like Ambien as the passport to get into sleep is alien.

Conventional wisdom always says that insomnia is somehow related to anxiety or stress levels, perhaps aggravated by drinking too many cups of real coffee. Greene comes up with a simple and practical explanation of what insomnia is. Insomnia means nothing more than you cannot get the number of hours of sleep you need to feel good about yourself and function efficiently. There is no reason for this. It is nothing more than a failure to sleep. There should be no pejorative implication. To use stress as an excuse is to blame the person for being weak or neurotic when there is no reason to blame yourself or anyone else. Instead of looking for some psychological explanation or a less judgemental physical cause, we should just accept that it happens to about 20% of the population at one time or another during their lives. Such a vast number of people yet so little is spent on researching the condition and its causes. Greene comments that the National Institutes of Health in the Europe spent less than $20m in 2005, whereas US spent more than $120m promoting Ambien in the same year. This is neither to praise nor condemn Ambien. It is your priorities that must be asked about this. Why bother to spend Government money on researching the cause of a condition when private capital has already invented Ambien as a cure for it? She debates what we really understand about cause and effect. It is so easy to get the cart before the horse, or should that be the other way round? Perhaps conventional wisdom has also got things back-to-front. Instead of stress and anxiety being the cause of insomnia, perhaps living with insomnia makes you stressed and anxious. Who is to say in these more modern times, that we did not have disturbed sleep patterns in past times living on the land? Folk tales may tell us that we went to sleep when dusk fell and waited for the cock to crow before waking. But was that actually the case? Who can say what the real biological norms were before electricity came along and gave everyone the chance to live through the darkness. As it stands, no researcher can actually explain why we have to sleep nor why some people sleep more than others. It is all guesswork. All that we can say with any certainty is that those who are deprived of sleep do not do as well as those who sleep through the night. The sleepless so often end up demotivated, their sense of humour worn thin, their judgement warped. Some grow fat. Others find their immune system affected. Sleep seems so indispensable yet no-one can really control it. Greene describes everything she has tried over the years from relaxation therapies to medication like Ambien, but concludes that, like any intimate relationship, how we relate to sleep is always personal. She is a passionate advocate for greater patient power to persuade disinterested bodies to research insomnia. For one who has had to depend on Ambien and the other medications for so long, she feels she and all other sufferers deserve better answers than those served up by the pharmaceutical companies. For one who has never had problems sleeping nor had to take Ambien, Insomniac was a riveting insight into the condition and the problems it causes. Required reading for everyone who reads this article.

Which is more important? The plumbing or emotions?

August 14th, 2008

Modern medical textbooks have all become so much more informative. A simple statement reflecting the vast amount of knowledge that has been accumulated through research over the last one hundred years. Yet, when you look at these books, you are confronted by mountains of facts about increasingly minute processes within the body. Students are expected to be impressed by the depth of knowledge because instead of one sentence approximating how a muscle works, there are now whole chapters devoted to the thin muscle filaments containing multiple proteins. Instead of simple engineering analogies of muscles and cables, human knowledge has become obsessed by the identification of ever more complex chemical and molecular processes. This is my wood-for-the-trees moment.

Erectile dysfunction can now be described in terms of complex chemical interactions and illustrated with wonderful diagrams. There are still all kinds of analogies with hydraulic engineering, but the sophistication of the functional analysis is breathtaking. However, it is not a part of the medical books to observe and describe the entirely human context in which the erection is supposed to operate. A single male may masturbate. A heterosexual couple may engage in sexual intercourse. A homosexual couple may offer mutual manual satisfaction, oral or anal intercourse. Multiple partners may engage in group sex. Many different social taboos would potentially be breached in any more detailed explanation. The common denominators are that the party or parties are expressing their sexuality in the ways that give them the most pleasure. The greater the pleasure, the greater the incentive to engage in the activity and the greater the disappointment if success is not achieved.

Will medical treatment be asked for and a success? In part, this will be determined by the nature of the relationship. Where the relationship is socially disapproved, the man may well not seek treatment at all because of fear. A physical examination might reveal different types of sexual activity, or a chance remark in the consultation might expose the forbidden practices. This is ironic. If the parties to the relationship have a strong mutual commitment and lovingly support each other, the likelihood is that the co-operation between all involved would produce excellent medical outcomes. Well-established sexual intimacy and commitment preserve the right level of desire and motivate everyone to getting a solution that works well. Were it not for online pharmacies and their willingness to supply medications like cialis without prescription, many partnerships might never be able to get appropriate treatment of any kind.

Unfortunately, many partnerships do not get treatment for the underlying causes of the dysfunction. Although most will know that the dysfunction can be a symptom of diabetes and cardiovascular diseases, fear of exposure may force the couples or groups to ignore or deny the problem until it is too late for the easy treatment represented by cialis to continue on its own. By then, the chances of an effective treatment for the underlying cause may be remote.

This is two completely different cultural imperatives in conflict. Men are socially conditioned to believe that they will always be able to have an erection. Any publicly acknowledged failure means shame. Yet they are only allowed to have erections in certain very carefully defined social situations. Step outside those situations and you are into potentially disapproved or even criminal territory. In theory, doctors are bound by duties of confidentiality, but the fear of exposure means that many men and their partners do not get treatment when the research shows that couples who are in love and share a strong commitment to their relationship are the ones who would most benefit from that treatment.